Hydrochloric Acid → HCID 86734135, compound

HRID 1729802Notes

Reaction equation

HRID 1729802 reaction equation
C([CH:3]([CH2:19][C:20]([OH:22])=[O:21])[N:4]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:5][C:6]1C=CC=CC=1)C.[ClH:23].[H][H]>[Pd].C(O)C>[ClH:23].[CH2:5]([N:4]([CH2:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:3][CH2:19][C:20]([OH:22])=[O:21])[CH3:6]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 86734137HCID 86734137, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 86734135HCID 86734135, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 192.8 parts of ethyl N-[2(ethoxycarbonyl)-ethyl]-N-(phenylmethyl)-β-alanine and 280 parts of absolute ethanol is stirred in an hydrogenation vessel. Then there are added 45 parts of hydrochloric acid solution. After cooling, 10 parts of palladium-on-charcoal catalyst 5% are added and the whole is shaken at room temperature while one equivalent of hydrogen is taken up. The catalyst is filtered off and the filtrate is evaporated, yielding ethyl N-[2-(ethoxycarbonyl)ethyl]-β-alanine hydrochloride as an oily residue.

Workup

  1. temperatureAfter cooling
  2. filtrationThe catalyst is filtered off
  3. customthe filtrate is evaporated

Sources & evidence

ORD record
ord-f042c27a6b8444af8a218b1c07bb1d74
Source dataset
uspto-grants-1976_11
Patent number
US03989707

Reaction notes

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