HCID 21500250, compound → HCID 21500251, compound

HRID 1729807Notes

Reaction equation

HRID 1729807 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH:11]([CH3:19])[CH2:10]2)=[C:4]([N+:20]([O-])=O)[CH:3]=1.[H][H]>[Ni].O1CCCC1>[NH2:20][C:4]1[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][C:5]=1[NH:8][CH:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][CH3:18])=[O:16])[CH:11]([CH3:19])[CH2:10]1

Participants

5

Reactant 2

HCID 21500250HCID 21500250, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21500251HCID 21500251, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 39.6 parts of methyl 4-(4-chloro-2-nitrophenylamino)-2-methyl-1-piperidinecarboxylate and 450 parts of tetrahydrofuran is hydrogenated at 40 lbs./sq. inch and at room temperature with 2 parts of raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off. The filtrate is evaporated, yielding methyl 4-(2-amino-4-chlorophenylamino)-2-methyl-1-piperidinecarboxylate as an oily residue.

Workup

  1. customat room temperature
  2. filtrationthe catalyst is filtered off
  3. customThe filtrate is evaporated

Sources & evidence

ORD record
ord-83e97be998c542e3a83f0db94c0d9164
Source dataset
uspto-grants-1976_11
Patent number
US03989707

Reaction notes

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