反应详情

1.45 g. 3-(5-nitro-1-methyl-2-imidazolyl)-6-amino-s-triazolo [4,3-b]pyridazine was boiled under reflux with 22 ml. acetic anhydride for 1.5 hours at 160° C. bath temperature, the solution obtained was then mixed with charcoal, suction filtered while still hot, washed with a little acetic anhydride and then with ether and dried for 3 hours at 120° C. There was thus obtained 0.79 g. of the desired 3-(5-nitro-1-methyl-2-imidazolyl)-6-acetamido-s-triazolo [4,3-b]pyridazine in the form of yellow-white crystals which melt at 238° - 239° C. and show a change above 230° C.

1. temperatureunder reflux with 22 ml
2. customthe solution obtained
3. filtrationfiltered while still hot,
4. washwashed with a little acetic anhydride
5. dry with materialwith ether and dried for 3 hours at 120° C
6. custommelt at 238° - 239° C.
7. customa change above 230° C.