Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 4-(((2-acetamido-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoate | HCID 136354639 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | Pteroic Acid | HCID 135398749 | — |
Reaction Steps
The ester (2.64 g) is hydrolyzed by heating with 350 ml of 0.1 N sodium hydroxide at 100° C for 30 minutes (under nitrogen and protected from light). The solution is cooled to 20° C and adjusted to pH 3 with concentrated hydrochloric acid. The precipitate is collected by centrifugation at 300 rpm. After washing twice with water and freeze drying, the product pteroic acid is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03989812 |
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| Source dataset | uspto-grants-1976_11 |
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| ORD ID | ord-0c954ba6682a4ef2b89b217437e56b9b |
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| Source note | uspto-grants-1976_11 |
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