Hydrochloric Acid → Fluorene-2-glyoxylic acid

Participants

Reaction Steps

A mixture of ethyl fluorene-2-glyoxylic acid (9.95 g) and sodium hydroxide (1.60 g) in 50% aqueous ethanol (100 ml) is refluxed for 0.5 hour, cooled and acidified to pH 2.0 with 10% HCl. The reaction mixture is extracted with ether, and the ether extracts dried (MgSO4) and evaporated. The residue is crystallized from benzene-hexane (Darco) to give the title compound (7.1 g. mp 135°-137°). The analytical sample is prepared by recrystallization from benzenehexane: mp 139°-140°.

Provenance & Evidence