反应详情

A mixture of ethyl fluorene-2-glyoxylic acid (9.95 g) and sodium hydroxide (1.60 g) in 50% aqueous ethanol (100 ml) is refluxed for 0.5 hour, cooled and acidified to pH 2.0 with 10% HCl. The reaction mixture is extracted with ether, and the ether extracts dried (MgSO4) and evaporated. The residue is crystallized from benzene-hexane (Darco) to give the title compound (7.1 g. mp 135°-137°). The analytical sample is prepared by recrystallization from benzenehexane: mp 139°-140°.

1. temperatureis refluxed for 0.5 hour
2. temperaturecooled
3. extractionThe reaction mixture is extracted with ether
4. dry with materialthe ether extracts dried (MgSO4)
5. customevaporated
6. customThe residue is crystallized from benzene-hexane (Darco)