Isopropanol → HCID 21498784, compound

HRID 1729989Notes

Reaction equation

HRID 1729989 reaction equation
C([N:9]1[CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]=2[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.CC(O)C>O.OS(O)(=O)=O>[CH2:11]1[CH2:10][NH:9][CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]1=2

Participants

5

Reactant 2

HCID 3776IsopropanolHCID 214987793-Benzoyl-2,3,4,6-tetrahydrobenzo[c][2,7]naphthyridin-5(1H)-one

Product 1

HCID 21498784HCID 21498784, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 1118Sulfuric AcidSolvent2×

Procedure

A solution of 7.7 g (0.025 m) of 3-benzoyl-1,2,3,4-tetrahydrobenzo[c][2,7]naphthyridin-5(6H)-one in 30 ml of water, 10 ml of H2SO4, and 200 ml of 2-propanol was refluxed for 20 hr. After cooling, the solid was filtered and recrystallized from water, mp 292°-295° C. By analysis, this material contains 0.7 mole of H2SO4 per mole of base and was used as is for alkylation.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered
  3. customrecrystallized from water, mp 292°-295° C

Sources & evidence

ORD record
ord-a5f8355d9316499f8b0646878de3c3ca
Source dataset
uspto-grants-1976_11
Patent number
US03991064

Reaction notes

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