Hydrochloric Acid → 4-(1,3,4,9b-Tetrahydro-5-methyl-2H-indeno[1,2-c]-pyridin-2-yl)butyric acid ethyl ester

HRID 1729994Notes

Reaction equation

[CH3:1][C:2]1[C:3]2[C:8]([CH:9]3[C:14]=1[CH2:13][CH2:12][NH:11][CH2:10]3)=[CH:7][CH:6]=[CH:5][CH:4]=2.[CH2:15]([O:17][C:18](=[O:23])[CH2:19][CH2:20][CH2:21]Br)[CH3:16].Cl>>[CH2:15]([O:17][C:18](=[O:23])[CH2:19][CH2:20][CH2:21][N:11]1[CH2:12][CH2:13][C:14]2=[C:2]([CH3:1])[C:3]3[C:8]([CH:9]2[CH2:10]1)=[CH:7][CH:6]=[CH:5][CH:4]=3)[CH3:16]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 76300Ethyl 4-bromobutyrate

HCID 214987881,3,4,9b-tetrahydro-5-methyl-2H-indeno[1,2-c]pyridine

Product 1

HCID 540438594-(1,3,4,9b-Tetrahydro-5-methyl-2H-indeno[1,2-c]-pyridin-2-yl)butyric acid ethyl ester

Procedure

1,3,4,9b-Tetrahydro-5-methyl-2H-indeno[1,2-c]-pyridine and 4-bromobutyric acid ethyl ester are reacted in accordance with the process described in Example 1. The hydrochloride of the title compound has a M.P. of 186°-188° from ethanol/acetone.

Sources & evidence

ORD record: ord-36115d808b064362bf1d6332cd5a0f90
Source dataset: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03991066

Reaction notes

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