HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 3-Methyl-8-oximino-5,6,7,8-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | 2-Hydroxyquinoline | HCID 6038 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Methyl-8-oximino-5,6,7,8-tetrahydroquinoline | HCID 136230260 | — |
Reaction Steps
The quinolinone (30g), hydroxylamine hydrochloride (14g), sodium hydroxide (9g), ethanol (165ml) and water (65ml) were stirred and refluxed for 2 hours. Water (100ml) was added and the product was allowed to crystallise overnight. The crystals were removed by filtration and washed with water and dried to give 3-methyl-8-oximino-5,6,7,8-tetrahydroquinoline (27.5g) mp 188° C. Found: C,68.5; H,6.9; N,15.4, C10H12N2O requires C,68.2; H,6.9; N,15.1%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03991065 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-9db2f02d70aa412d86fcac58dd0579df |
| Source note | uspto-grants-1976_11 |