反应详情

The quinolinone (30g), hydroxylamine hydrochloride (14g), sodium hydroxide (9g), ethanol (165ml) and water (65ml) were stirred and refluxed for 2 hours. Water (100ml) was added and the product was allowed to crystallise overnight. The crystals were removed by filtration and washed with water and dried to give 3-methyl-8-oximino-5,6,7,8-tetrahydroquinoline (27.5g) mp 188° C. Found: C,68.5; H,6.9; N,15.4, C10H12N2O requires C,68.2; H,6.9; N,15.1%.

1. temperaturerefluxed for 2 hours
2. customto crystallise overnight
3. customThe crystals were removed by filtration
4. washwashed with water
5. customdried