反应详情

To 75 ml. dry tetrahydrofuran were added 6.8 g. imidazole and 12.075 g. N-2-phenoxyethyl-N-propylcarbamoyl chloride. The reactants were boiled together under reflux for 24 hours, cooled to room temperature and filtered to remove imidazole hydrochloride. The solvent was then removed by evaporation from the steam bath, the last traces being removed under vacuum. An oily residue remained which was extracted into ether, washed with water, dried over anhydrous sodium sulphate, the solvent removed and the residual oil distilled under vacuum, to give 1-(N-2-phenoxyethyl-N-propylcarbamoyl) imidazole, boiling point 209° C./1.0 mm.

1. temperatureunder reflux for 24 hours
2. filtrationfiltered
3. customto remove imidazole hydrochloride
4. customThe solvent was then removed by evaporation from the steam bath
5. customthe last traces being removed under vacuum
6. extractionwas extracted into ether
7. washwashed with water
8. dry with materialdried over anhydrous sodium sulphate
9. customthe solvent removed
10. distillationthe residual oil distilled under vacuum