Sodium Hydroxide → HCID 23693872, compound

HRID 1730048Notes

Reaction equation

HRID 1730048 reaction equation
[C:1]1([CH:7]([N:9]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][N:11]=[CH:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+:18]>CC(O)C>[Na+:18].[C:1]1([CH:7]([N:9]2[C:13]([C:14]([O-:16])=[O:15])=[CH:12][N:11]=[CH:10]2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 297427Desethyl-etomidate

Product 1

HCID 23693872HCID 23693872, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 17.7 parts of (-)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid, 3.28 parts of sodium hydroxide and 120 parts of 2-propanol is stirred and refluxed until the reaction mixture becomes homogeneous and thereafter for 1 further hour. During reflux part of the product crystallizes out. The reaction mixture is allowed to cool to room temperature and the precipitated product is filtered off. The product is washed with 2 -propanol and dried in vacuo, yielding (-)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic acid sodium salt.

Workup

  1. temperaturerefluxed until the reaction mixture
  2. temperatureDuring reflux part of the product
  3. customcrystallizes out
  4. filtrationthe precipitated product is filtered off
  5. washThe product is washed with 2 -propanol
  6. customdried in vacuo

Sources & evidence

ORD record
ord-fcfecd1575a344288b4ed8f707b44b4b
Source dataset
uspto-grants-1976_11
Patent number
US03991072

Reaction notes

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