HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-amitriptyline → Amitriptyline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-amitriptyline | HCID 103696 | — |
| Reactant | D-Tartaric acid | HCID 439655 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Amitriptyline | HCID 2160 | — |
Reaction Steps
1-Chloro-amitriptyline (196 mg) in 3 ml. absolute ethanol was added to an ethanolic solution of 1.1 eq. d-tartaric acid and warmed for 5-10 mins. The title compound was precipitated with ethyl ether as a white powder. After purity and identification checks, the overall yield from amitriptyline base was 32%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03991103 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-b196b6985ee74a0ebcf6527350330854 |
| Source note | uspto-grants-1976_11 |