Sodium Hydroxide → HCID 21401588, compound

HRID 1730125Notes

Reaction equation

HRID 1730125 reaction equation
[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([O:19]CC)=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8].C(OC(COC1C=CC(F)=CC=1)CCCN(CC#CCCCC(OC)=O)S(C)(=O)=O)(=O)C.[OH-].[Na+]>>[OH:1][CH:2]([CH2:22][O:23][C:24]1[CH:25]=[CH:26][C:27]([F:30])=[CH:28][CH:29]=1)[CH2:3][CH2:4][CH2:5][N:6]([CH2:11][C:12]#[C:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18])[S:7]([CH3:10])(=[O:9])=[O:8]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 21401586Ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}heptanoateHCID 21401649HCID 21401649, compound

Product 1

HCID 21401588HCID 21401588, compound

Procedure

The synthesis of this compound is carried out as described in Example 1, Step E except that the ethyl 7-{N-[4-hydroxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido} -heptanoate is replaced by an equimolar amount of methyl 7-{N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamido}-hept- 5-ynoate and the amount of sodium hydroxide is doubled. The product of this reaction is the subject compound.

Workup

  1. customThe synthesis of this compound

Sources & evidence

ORD record
ord-bdfb3d3442144665beeae132fe157b0e
Source dataset
uspto-grants-1976_11
Patent number
US03991106

Reaction notes

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