反应详情

A mixture of 27 parts of 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanenitrile, 27 parts of potassium hydroxide and 100 parts of 1,2-ethanediol is stirred and refluxed for 48 hours. The reaction mixture is allowed to cool to room temperature, poured onto water (800 parts) and acidified with an excess of a concentrated hydrochloric acid solution. The precipitated product is filtered off and crystallized from ethanol, yielding 18 parts of 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanoic acid; mp. 220°-222° C.

1. temperaturerefluxed for 48 hours
2. additionpoured onto water (800 parts)
3. filtrationThe precipitated product is filtered off
4. customcrystallized from ethanol