Hydrochloric Acid → Methyl 2,4-dichloro-alpha-(2,6-dichlorophenyl)benzenepropanoate

Participants

Reaction Conditions

Reaction Steps

Gaseous hydrogen chloride is introduced through 200 parts of methanol till saturation, while cooling at 0° C. Then there are added 17 parts of 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanoic acid and the whole is stirred and refluxed for 72 hours. The reaction mixture is poured onto water and the product is extracted twice with 1,1'-oxybisethane. The combined extracts are washed successively once with a diluted sodium bicarbonate solution and twice with water, dried, filtered and evaporated. The residue is crystallized from methanol, yielding 13.11 parts of methyl 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanoate; mp. 115.1° C.

Provenance & Evidence