反应详情

温度

0 °C

Gaseous hydrogen chloride is introduced through 200 parts of methanol till saturation, while cooling at 0° C. Then there are added 17 parts of 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanoic acid and the whole is stirred and refluxed for 72 hours. The reaction mixture is poured onto water and the product is extracted twice with 1,1'-oxybisethane. The combined extracts are washed successively once with a diluted sodium bicarbonate solution and twice with water, dried, filtered and evaporated. The residue is crystallized from methanol, yielding 13.11 parts of methyl 2,4-dichloro-α-(2,6-dichlorophenyl)benzenepropanoate; mp. 115.1° C.

1. temperaturerefluxed for 72 hours
2. additionThe reaction mixture is poured onto water
3. extractionthe product is extracted twice with 1,1'-oxybisethane
4. washThe combined extracts are washed successively once with a diluted sodium bicarbonate solution and twice with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. customThe residue is crystallized from methanol