Hydrochloric Acid → 2-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole Hydrochloride

HRID 1730188Notes

Reaction equation

HRID 1730188 reaction equation
[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1.[ClH:16]>>[ClH:16].[NH2:1][N:2]1[NH:6][CH:5]=[C:4]([C:7]2[N:8]([CH3:15])[C:9]([N+:12]([O-:14])=[O:13])=[CH:10][N:11]=2)[S:3]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 213908162-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole

Product 1

HCID 213908152-(2-Amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole Hydrochloride

Procedure

Four grams of 2-(2-amino-5-thiadiazolyl)-1-methyl-5-nitroimidazole is added to concentrated hydrochloric acid. The resultant precipitate of the hydrochloride is filtered off and air dried; melting point 249° C. with decomposition. When the hydrochloride is added to water, the free base is formed again without the necessity of using alkali.

Workup

  1. filtrationThe resultant precipitate of the hydrochloride is filtered off
  2. customair dried
  3. additionWhen the hydrochloride is added to water
  4. customthe free base is formed again without the necessity of using alkali

Sources & evidence

ORD record
ord-6e55b1f1e9654aa6b54f015aae7f3e5d
Source dataset
uspto-grants-1976_11
Patent number
US03991200

Reaction notes

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