Piperidine → HCID 20361138, compound

HRID 1730231Notes

Reaction equation

HRID 1730231 reaction equation
I[CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7].[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>C1C=CC=CC=1>[N:10]1([CH2:2][CH2:3][CH2:4][CH2:5][C:6]([O:8][CH3:9])=[O:7])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 334445methyl 5-iodopentanoate

Product 1

HCID 20361138HCID 20361138, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

30.0 g. (0.124 mole) of methyl δ-iodovalerate and 42.5 g. (0.50 mole) of piperidine were dissolved in 250 ml. of benzene and heated at 60° C for 3 hours with stirring. A colorless solid began to appear shortly after the materials were combined. The solid was removed by suction filtration, and the benzene evaporated to give methyl δ-piperidinovalerate which distilled as 23.5 g. (95%) of colorless liquid, b.p. 122°-24° C (12.5 mm.).

Workup

  1. customThe solid was removed by suction filtration
  2. customthe benzene evaporated

Sources & evidence

ORD record
ord-f3575b4532894a988e57e6cc7f9b800c
Source dataset
uspto-grants-1976_11
Patent number
US03991194

Reaction notes

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