Hydrochloric Acid → 4-Chloro-2-fluoroaniline

HRID 1730240Notes

Reaction equation

HRID 1730240 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH:6]C(=O)C)=[C:4]([F:12])[CH:3]=1.Cl>>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([NH2:6])=[C:4]([F:12])[CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 8531744'-Chloro-2'-fluoroacetanilide

Product 1

HCID 938984-Chloro-2-fluoroaniline

Procedure

4'-Chloro-2'-fluoroacetanilide is refluxed in a mixture of a lower alcohol (50%) (e.g. ethanol) and concentrated hydrochloric acid (50%) for several hours (e.g.5 or more) at 70°-90° C and atmospheric pressure. The solvent mixture is removed at a reduced pressure of 100 to 300 mm. Hg. and 20°-50° C to leave a residue of the hydrochloride salt of 4-chloro-2-fluoroaniline.

Workup

  1. customThe solvent mixture is removed at a reduced pressure of 100 to 300 mm. Hg

Sources & evidence

ORD record
ord-ef4ec45f60684e3c88c0c9e8ac035443
Source dataset
uspto-grants-1976_11
Patent number
US03992189

Reaction notes

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