反应详情

4-Trifluoromethyl-o-phenylenediamine (8.0 grams) was added to 80 ml. of ethyl oxalate and the resulting mixture was heated to reflux and refluxed for two hours. A precipitate formed during this period. The reaction mixture was then cooled to room temperature and filtered to separate the precipitate, m.p. 344°-346° C. (dec.) The product was identified as the expected 6-trifluoromethyl-2(1H), 3(4H)-quinoxalinedione, by IR, TLC, NMR, and microanalysis.

1. temperatureto reflux
2. temperaturerefluxed for two hours
3. customA precipitate formed during this period
4. filtrationfiltered
5. customto separate the precipitate, m.p. 344°-346° C. (dec.) The product