4-Trifluoromethyl-1,2-phenylenediamine → 1,4-Dihydro-6-(trifluoromethyl)-2,3-quinoxalinedione

Participants

Reaction Steps

4-Trifluoromethyl-o-phenylenediamine (8.0 grams) was added to 80 ml. of ethyl oxalate and the resulting mixture was heated to reflux and refluxed for two hours. A precipitate formed during this period. The reaction mixture was then cooled to room temperature and filtered to separate the precipitate, m.p. 344°-346° C. (dec.) The product was identified as the expected 6-trifluoromethyl-2(1H), 3(4H)-quinoxalinedione, by IR, TLC, NMR, and microanalysis.

Provenance & Evidence