Thiosemicarbazide → 1-(5-Phenylvaleroyl)-3-thiosemicarbazide

HRID 1730291Notes

Reaction equation

HRID 1730291 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:14][NH:15][C:16]([NH2:18])=[S:17]>CN(C)C=O>[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][C:11]([NH:14][NH:15][C:16]([NH2:18])=[S:17])=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 2723789ThiosemicarbazideHCID 109654605-phenylpentanoyl Chloride

Product 1

HCID 214972721-(5-Phenylvaleroyl)-3-thiosemicarbazide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 9.9 g. of 5-phenylvaleroylchloride and 4.6 g. of thiosemicarbazide was stirred in 20 ml. of dimethylformamide for 6 hours at 22° C. The solvent was evaporated and 10 ml. of water and 10 ml.of ether were added to the residue. The precipitate was filtered off to give the intermediate 1-(5-phenylvaleroyl)-3-thiosemicarbazide, m.p. 140°-141° C.

Workup

  1. additionA mixture of 9.9 g
  2. customThe solvent was evaporated
  3. additionof ether were added to the residue
  4. filtrationThe precipitate was filtered off

Sources & evidence

ORD record
ord-ab052f9e35ab41e59ff356d7ba0f136d
Source dataset
uspto-grants-1976_11
Patent number
US03992396

Reaction notes

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