Ethanol → HCID 178481960, compound

HRID 1730300Notes

Reaction equation

HRID 1730300 reaction equation
C([N:3]([CH2:6]C)CC)C.[CH3:8][N:9]1[C:13]([SH:14])=CN(O)[NH:10]1.[Cl:16][C:17]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[C:18]=1[CH2:19]Cl.C([OH:28])C>>[CH3:8][N:9]1[C:13]([S:14][CH2:19][C:18]2[C:17]([Cl:16])=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:25])=[N:3][C:6]([OH:28])=[N:10]1

Participants

5

Reactant 4

HCID 702EthanolHCID 8471TriethylamineHCID 748322,6-Dichlorobenzyl chlorideHCID 21497350HCID 21497350, compound

Product 1

HCID 178481960HCID 178481960, compound

Procedure

11.1 g of triethylamine are added at room temperature to a suspension of 13.1 g of 1-methyl-3-hydroxy-5-mercaptotriazole and 27.4 g of 2,6-dichlorobenzyl chloride in 100 ml of ethanol. The exothermic reaction causes the temperature to rise to about 45° C. The clear solution is then stirred for 30 minutes and evaporated to dryness. The solid residue is treated with abundant water and the undissolved material is filtered off. It is recrystallised from methanol/acetone.

Workup

  1. customThe exothermic reaction
  2. customto rise to about 45° C
  3. customevaporated to dryness
  4. additionThe solid residue is treated with abundant water
  5. filtrationthe undissolved material is filtered off
  6. customIt is recrystallised from methanol/acetone

Sources & evidence

ORD record
ord-55120f9d77204b2ca0d69350133405de
Source dataset
uspto-grants-1976_11
Patent number
US03992399

Reaction notes

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