反应详情

温度

70 °C

2-Cyclohexylethyl bromide (1.9 g.) in dimethylformamide (10 ml.) was added to 4-benzamidopiperidine (2.2 g.), diisopropylamine (4 ml.) and a trace ofsodium iodide in dimethylformamide (10 ml.). The mixture was heated at 70° C for 16 hours, cooled, poured into water, and extracted with methylene chloride. The washed and dried extracts were evaporated and the solid residue was recrystallised from ethanol to give the product (1.25 g.), m.p. 174°-5° C. (Found: C, 76.4; H, 9.5; N, 8.9. C20H30H2O requires C, 76.4; H, 9.6; N, 8.9%).

1. temperaturecooled
2. extractionextracted with methylene chloride
3. washThe washed
4. customdried extracts
5. customwere evaporated
6. customthe solid residue was recrystallised from ethanol
7. customto give the product (1.25 g.), m.p. 174°-5° C. (Found: C, 76.4; H, 9.5; N, 8.9. C20H30H2O requires C, 76.4; H, 9.6; N, 8.9%)