HRID1730347

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID118120

N-(Piperidin-4-yl)benzenecarboximidic acid

C12H16N2O

HCID15149389

4-(2-Bromoethyl)-1,2-dichlorobenzene

C8H7BrCl2

PRODUCTS

生成物

结构：O=C(NC1CCN(CCc2ccc(Cl)c(Cl)c2)CC1)c1ccccc1

HCID21413253

未命名化合物

收率 94.2%

CONDITIONS

反应条件

温度: 100 °C

PROCEDURE

实验过程

4-Benzamidopiperidine (204 mg.) and anhydrous potassium carbonate (138 mg.)were intimately ground together and added to 2-(3,4-dichlorophenyl)ethyl bromide (254 mg.). The resulting paste was heated at 100° C for 2 hours to give a hard solid. This was broken up, washed well with water andether and dried to give the title compound (355 mg.). Recrystallisation from ethanolic hydrogen chloride and ether gave the hydrochloride (237 mg.), m.p. 286.0° C. (Found: C, 58.2; H, 5.8; N, 6.8. C20H22Cl2N2O.HCl requires C, 58.05; H, 5.6; N, 6.8%).

WORKUP

后处理

customto give a hard solid
washwashed well with water andether
customdried