Potassium Carbonate → HCID 21430598, compound

HRID 1730352Notes

Reaction equation

HRID 1730352 reaction equation
[O:1]([CH2:8][CH2:9]Br)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:11]([NH:19][CH:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)(=[O:18])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(=O)([O-])[O-].[K+].[K+]>>[O:1]([CH2:8][CH2:9][N:23]1[CH2:24][CH2:25][CH:20]([NH:19][C:11](=[O:18])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:21][CH2:22]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 68526Benzene, (2-bromoethoxy)-HCID 118120N-4-Piperidylbenzamide

Product 1

HCID 21430598HCID 21430598, compound

Procedure

2-Phenoxyethylbromide (2.01 g.), 4-benzamidopiperidine (2.04 g.) and anhydrous potassium carbonate (1.38 g.) were reacted together according tothe procedure of Example 51. The title compound as its hydrochloride (2.06 g.) had m.p. 207° C. (Found: C, 67.0; H, 7.1; N, 7.7. C20H24N2O2.HCl requires C, 67.3; H, 7.1; N, 7.85%).

Sources & evidence

ORD record
ord-bd81182d4db54439985f06b5ce57678c
Source dataset
uspto-grants-1976_11
Patent number
US03992389

Reaction notes

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