HCID 178463381, compound → HCID 21497533, compound

HRID 1730396Notes

Reaction equation

HRID 1730396 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:12][CH:13]([CH3:28])[C:14]([CH2:16][N:17]3[C:21](=[O:22])[C:20]4=[CH:23][CH:24]=[CH:25][CH:26]=[C:19]4[C:18]3=[O:27])=O)[CH2:9][N:8]=[C:7]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[Cl:35])[C:6]=2[CH:36]=1>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:14]([CH2:16][N:17]4[C:21](=[O:22])[C:20]5=[CH:23][CH:24]=[CH:25][CH:26]=[C:19]5[C:18]4=[O:27])=[C:13]([CH3:28])[N:12]=[C:10]3[CH2:9][N:8]=[C:7]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=3[Cl:35])[C:6]=2[CH:36]=1

Participants

3

Reactant 1

HCID 178463381HCID 178463381, compound

Product 1

HCID 21497533HCID 21497533, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

In the manner given in example 20 a suspension of 7-chloro-5-(o-chlorophenyl)-2-[(3-phthalimido-1-methylacetonyl)amino]-3H-1,4-benzodiazepine, ethylene ketal in concentrated sulfuric acid is stirred at room temperature under nitrogen for 18 hours and the reaction mixture poured onto ice, treated with base and the product isolated to give 8-chloro-1-(phthalimidomethyl)-2-methyl-6-(o-chlorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine.

Workup

  1. additionthe reaction mixture poured onto ice
  2. additiontreated with base
  3. customthe product isolated

Sources & evidence

ORD record
ord-59da0d9e19af4a64b91d7fb8ec3acd45
Source dataset
uspto-grants-1976_11
Patent number
US03992408

Reaction notes

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