Hydrazine hydrate (1:1) → HCID 21497497, compound

HRID 1730401Notes

Reaction equation

HRID 1730401 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][N:18]4C(=O)C5=CC=CC=C5C4=O)=[CH:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:8]=2[CH:35]=1)([O-:3])=[O:2].O.NN>C(O)C>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]2[N:13]3[C:14]([CH2:17][NH2:18])=[CH:15][N:16]=[C:12]3[CH2:11][N:10]=[C:9]([C:29]3[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=3)[C:8]=2[CH:35]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21497539HCID 21497539, compound

Product 1

HCID 21497497HCID 21497497, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 28, 8-nitro-1-(phthalimidomethyl)-6-phenyl-4H-imidazo[1,2-a][1,4]-benzodiazepine is reacted at room temperature with hydrazine hydrate, dissolved in ethanol to give 8-nitro-1-(aminomethyl)-6-phenyl-4H-imidazo[1,2-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-06b1ed037b5f4811b23c7d55b1b8f2bd
Source dataset
uspto-grants-1976_11
Patent number
US03992408

Reaction notes

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