Hydrazine hydrate (1:1) → HCID 21497505, compound

HRID 1730404Notes

Reaction equation

HRID 1730404 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][N:17]4C(=O)C5=CC=CC=C5C4=O)=[CH:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])[C:7]=2[CH:35]=1.O.NN>C(O)C>[F:37][C:2]([F:1])([F:36])[C:3]1[CH:4]=[CH:5][C:6]2[N:12]3[C:13]([CH2:16][NH2:17])=[CH:14][N:15]=[C:11]3[CH2:10][N:9]=[C:8]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])[C:7]=2[CH:35]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21497597HCID 21497597, compound

Product 1

HCID 21497505HCID 21497505, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 28, 8-trifluoromethyl-1-(phthalimidomethyl)-6-(o-chlorophenyl)-4H-imidazo[1,2-a][1,4]benzodiazepine is reacted at room temperature with hydrazine hydrate, dissolved in ethanol, to give 8-trifluoromethyl-1-(aminomethyl)-6-(o-chlorophenyl)-4H-imidazo-[1,2-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-9963a2574d6547708fb001a26846e565
Source dataset
uspto-grants-1976_11
Patent number
US03992408

Reaction notes

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