Sodium Hydroxide → HCID 54559995, compound

HRID 1730426Notes

Reaction equation

HRID 1730426 reaction equation
C([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[C:20]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:25][CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:7][CH:6]=1)(=O)C.[OH-].[Na+]>[Pt]>[NH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][C:12]2[C:20]([S:21](=[O:24])(=[O:23])[NH2:22])=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][C:13]=2[NH:25][CH2:26][CH:27]([CH3:29])[CH3:28])=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54169641HCID 54169641, compound

Product 1

HCID 54559995HCID 54559995, compound

Reagents, catalysts & solvents 1

HCID 23939PlatinumCatalyst2×

Procedure

The mixture of 3.5 g of 4-(4-acetamidophenylmercapto)-3-isobutylamino-5-sulfamoylbenzoic acid, 35 ml of 2 N aqueous sodium hydroxide and some colloidal platinum is refluxedfor 1 hour under nitrogen, during which time the platinum coagulates. Aftercooling it is filtered, the filtrate acidified with acetic acid to a pH of 4-5, the precipitate formed is filtered off and recrystallized from aqueous ethanol, to yield the 4-(4-aminophenylmercapto)-3-isobutylamino-5-sulfamoylbenzoic acid melting at 250°-252°.

Workup

  1. filtrationAftercooling it is filtered
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customrecrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-2f43706aa1f649dfb1e082a01751e276
Source dataset
uspto-grants-1976_11
Patent number
US03992440

Reaction notes

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