反应详情

温度

0 °C

The preparation of the subject compound may also be accomplished as follows: 25 g. of 1,3-diaminoguanidine hydrochloride is dissolved in 1800 ml. of boiling ethanol. To this boiling solution, 28 g. of 4-chlorobenzaldehyde in 300 ml. of ethanol is added over a period of 8 hours. The reaction mixture is then cooled at 0° C. overnight, clarified, and the filtrate concentrated to 500 ml. volume and cooled at 0° C. 29 g. of precipitate is obtained. This is slurried in 300 ml.of water, the pH adjusted to 8-8.5 with sodium hydroxide solution, the slurry heated to boiling and filtered. Cooling the filtrate gives 18 g. ofessentially pure product melting at 243°-244° C., as in the previous preparation.

1. customThe preparation of the subject compound
2. concentrationthe filtrate concentrated to 500 ml
3. temperaturevolume and cooled at 0° C
4. customof precipitate is obtained
5. temperaturethe slurry heated
6. filtrationfiltered
7. temperatureCooling the filtrate
8. customgives 18 g