Thionyl Chloride → HCID 178521124, compound

HRID 1730483Notes

Reaction equation

HRID 1730483 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([OH:18])=O.S(Cl)([Cl:21])=O>>[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16]([Cl:21])=[O:18]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178524726HCID 178524726, compound

Product 1

HCID 178521124HCID 178521124, compound

Procedure

A mixture of 0.5 g of 4-hydroxy-8-trifluoromethyl-3 -quinoline-carboxylic acid in 5 ml of thionyl chloride was stirred at room temperature for 24 hours and the precipitate formed was recovered by vacuum filtration to obtain 0.4 g of 4-hydroxy-8-trifluoromethyl-3-quinoline-carboxylic acid chloride melting at 222° C.

Workup

  1. customthe precipitate formed
  2. filtrationwas recovered by vacuum filtration

Sources & evidence

ORD record
ord-9c960e990a0e4356ac17dfad6c20d1d2
Source dataset
uspto-grants-1976_11
Patent number
US03992540

Reaction notes

Loading…