2-Aminothiazole → HCID 178522561, compound

HRID 1730487Notes

Reaction equation

HRID 1730487 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([C:12]([F:15])([F:14])[F:13])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:16](Cl)=[O:17].[NH2:19][C:20]1[S:21][CH:22]=[CH:23][N:24]=1>>[S:21]1[CH:22]=[CH:23][N:24]=[C:20]1[NH:19][C:16]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=2)=[O:17]

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 178521123HCID 178521123, compound

Product 1

HCID 178522561HCID 178522561, compoundYield 56.6%

Procedure

Using the procedure of Step B of Example 1, 3.7 g of the acid chloride of Step A and 1.35 g of 2-amino-thiazole were reacted to obtain 2.58 g of N-[2-thiazolyl]-4-hydroxy- 7-trifluoromethyl-3-quinoline-carboxamide melting above 369° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-fe6b7fac80fc4d5db3b5bf8604ddec49
Source dataset
uspto-grants-1976_11
Patent number
US03992540

Reaction notes

Loading…