Trifluoroacetic acid → HCID 21498238, compound

Participants

Reaction Steps

1-Hydrazino-4-methylisoquinoline (5.0 g.) and trifluoroacetic acid (70 ml.)were heated at reflux for three hours. After removal of the excess trifluoroacetic acid, the residue was dissolved in chloroform and extracted with sodium carbonate solution. The organic layer was dried and concentrated and the residue was recrystallized from a cyclohexane-benzene(70/30) mixture to provide the product in a yield of 65%, m.p. 162°-164°C.

Provenance & Evidence