Trifluoroacetic acid → HCID 21498238, compound

HRID 1730488Notes

Reaction equation

HRID 1730488 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([CH3:13])=[CH:5][N:4]=1)[NH2:2].[F:14][C:15]([F:20])([F:19])[C:16](O)=O>>[F:14][C:15]([F:20])([F:19])[C:16]1[N:4]2[CH:5]=[C:6]([CH3:13])[C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21498234HCID 21498234, compound

Product 1

HCID 21498238HCID 21498238, compoundYield 65%

Procedure

1-Hydrazino-4-methylisoquinoline (5.0 g.) and trifluoroacetic acid (70 ml.)were heated at reflux for three hours. After removal of the excess trifluoroacetic acid, the residue was dissolved in chloroform and extracted with sodium carbonate solution. The organic layer was dried and concentrated and the residue was recrystallized from a cyclohexane-benzene(70/30) mixture to provide the product in a yield of 65%, m.p. 162°-164°C.

Workup

  1. temperature)were heated
  2. temperatureat reflux for three hours
  3. customAfter removal of the excess trifluoroacetic acid
  4. dissolutionthe residue was dissolved in chloroform
  5. extractionextracted with sodium carbonate solution
  6. customThe organic layer was dried
  7. concentrationconcentrated
  8. customthe residue was recrystallized from a cyclohexane-benzene(70/30) mixture
  9. customto provide the product in a yield of 65%, m.p. 162°-164°C.

Sources & evidence

ORD record
ord-540a9130aa6643e5bf19b419f1c8ba0f
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

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