Hydrochloric Acid → HCID 21498239, compound

HRID 1730489Notes

Reaction equation

HRID 1730489 reaction equation
[OH-].[K+].[F:3][C:4]([F:23])([F:22])[C:5]1[N:9]2[CH:10]=[C:11]([C:18]([O:20]C)=[O:19])[C:12]3[C:17]([C:8]2=[N:7][N:6]=1)=[CH:16][CH:15]=[CH:14][CH:13]=3.C(O)C.Cl>O>[F:23][C:4]([F:3])([F:22])[C:5]1[N:9]2[CH:10]=[C:11]([C:18]([OH:20])=[O:19])[C:12]3[C:17]([C:8]2=[N:7][N:6]=1)=[CH:16][CH:15]=[CH:14][CH:13]=3

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 21498221HCID 21498221, compound

Product 1

HCID 21498239HCID 21498239, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of potassium hydroxide (2.8 g., 0.05 mol.) and 3-trifluoromethyl-6-methoxycarbonyl-s-triazolo-[3,4-a]-isoquinoline (14.8 g., 0.05 mol.) was allowed to reflux in 280 ml. of ethanol for 12 hours. Removal of the solvent provided a residue which was dissolved in water andfiltered. The aqueous filtrate was neutralized with 2N hydrochloric acid and the product, 9.7 g. (70%) was collected by filtration; m.p. 290°C. (dec.).

Workup

  1. temperatureto reflux in 280 ml
  2. customRemoval of the solvent
  3. customprovided a residue which
  4. filtration(70%) was collected by filtration

Sources & evidence

ORD record
ord-b5a5d0a38bb94faaad535be8b6bd304d
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

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