Trifluoroacetic acid → HCID 21498232, compound

HRID 1730491Notes

Reaction equation

HRID 1730491 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][C:9]([O:13][CH3:14])=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[F:15][C:16]([F:21])([F:20])[C:17](O)=O>>[F:15][C:16]([F:21])([F:20])[C:17]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][CH:10]=[C:9]([O:13][CH3:14])[CH:8]=3

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21498230HCID 21498230, compound

Product 1

HCID 21498232HCID 21498232, compoundYield 20%

Procedure

A solution of 1-hydrazino-6-methoxyisoquinoline and excess trifluoroacetic acid was held at reflux for four hours. After removal of the excess acid, the residue was treated with potassium bicarbonate solution until neutral and filtered. The filter cake was recrystallized from ethanol to provide the product in a yield of 20%; m.p. 214°-215°C.

Workup

  1. temperatureat reflux for four hours
  2. customAfter removal of the excess acid
  3. additionthe residue was treated with potassium bicarbonate solution until neutral and
  4. filtrationfiltered
  5. customThe filter cake was recrystallized from ethanol
  6. customto provide the product in a yield of 20%

Sources & evidence

ORD record
ord-8616f397361d4660bcb60c0289b595df
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

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