1-Hydrazinoisoquinoline → 3-Acetoxymethyl-s-triazolo-[3,4-a]-isoquinoline

HRID 1730495Notes

Reaction equation

HRID 1730495 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[C:13]([O:16][CH:17](O)[C:18](O)=O)(=[O:15])[CH3:14]>C(Cl)(Cl)Cl>[C:13]([O:16][CH2:17][C:18]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3)(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 115573331-HydrazinoisoquinolineHCID 22133411Acetoxyglycolic acid

Product 1

HCID 214982183-Acetoxymethyl-s-triazolo-[3,4-a]-isoquinoline

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

1-Hydrazinoisoquinoline was heated with excess acetoxyglycolic acid. The residue was cooled, dissolved in chloroform and washed with sodium carbonate solution. The chloroform extracts were dried and concentrated invacuo to provide the crude product which was purified by recrystallization from benzene.

Workup

  1. temperatureThe residue was cooled
  2. washwashed with sodium carbonate solution
  3. dry with materialThe chloroform extracts were dried
  4. concentrationconcentrated invacuo

Sources & evidence

ORD record
ord-ec8c70329bf748aa9232107ce1873fb3
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

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