Trifluoroacetic acid → HCID 21498242, compound

HRID 1730496Notes

Reaction equation

HRID 1730496 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[F:15][C:16]([F:21])([F:20])[C:17](O)=O>>[F:15][C:16]([F:21])([F:20])[C:17]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][C:10]([O:13][CH3:14])=[CH:9][CH:8]=3

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 214982201-Hydrazinyl-7-methoxyisoquinoline

Product 1

HCID 21498242HCID 21498242, compoundYield 70%

Procedure

A solution of 1-hydrazino-7-methoxyisoquinoline in excess trifluoroacetic acid was allowed to reflux for 2 hours. Excess acid was removed in vacuo and the residue was slurried in water and treated with sodium bicarbonate solution. The solid was removed by filtration and recrystallized from cyclohexane to give the product in a yield of 70%; m.p. 152°-154°C.

Workup

  1. temperatureto reflux for 2 hours
  2. customExcess acid was removed in vacuo
  3. additiontreated with sodium bicarbonate solution
  4. customThe solid was removed by filtration
  5. customrecrystallized from cyclohexane
  6. customto give the product in a yield of 70%

Sources & evidence

ORD record
ord-cb8697c9166b4b75ada6cfd0dbd95a89
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

Loading…