Trifluoroacetic acid → HCID 21498217, compound

HRID 1730497Notes

Reaction equation

HRID 1730497 reaction equation
[NH:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH3:13])[CH:11]=2)[CH:6]=[CH:5][N:4]=1)[NH2:2].[F:14][C:15]([F:20])([F:19])[C:16](O)=O>>[F:14][C:15]([F:20])([F:19])[C:16]1[N:4]2[CH:5]=[CH:6][C:7]3[C:12]([C:3]2=[N:1][N:2]=1)=[CH:11][C:10]([CH3:13])=[CH:9][CH:8]=3

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21498236HCID 21498236, compound

Product 1

HCID 21498217HCID 21498217, compoundYield 20%

Procedure

A solution of 1-hydrazino-7-methylisoquinoline in excess trifluoroacetic acid was allowed to reflux for two hours. Removal of the excess acid in vacuo, treatment of the residue with sodium bicarbonate solution and filtration provided the crude product which was recrystallized from cyclohexane to give the product in a yield of 20%; m.p. 205°-206°C.

Workup

  1. temperatureto reflux for two hours
  2. customRemoval of the excess acid in vacuo, treatment of the residue
  3. filtrationwith sodium bicarbonate solution and filtration

Sources & evidence

ORD record
ord-55867833854d4bd5a2b458ea5632e3c4
Source dataset
uspto-grants-1976_11
Patent number
US03992539

Reaction notes

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