Benzene → HCID 21498286, compound

HRID 1730505Notes

Reaction equation

HRID 1730505 reaction equation
[CH2:1]([N:8]1[CH2:13]C=C(N2CCCC2)C(C)C1)[C:2]1[CH:7]=[CH:6][CH:5]=C[CH:3]=1.[CH2:20](Br)[C:21]#[CH:22].[OH2:24].[CH:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:13]([N:8]1[CH2:1][CH:2]([CH2:7][C:6]#[CH:5])[C:3](=[O:24])[CH:21]([CH3:22])[CH2:20]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

5

Reactant 4

HCID 241BenzeneHCID 962WaterHCID 7842Propargyl bromideHCID 21498285HCID 21498285, compound

Product 1

HCID 21498286HCID 21498286, compoundYield 50%

Procedure

A solution of 1-benzyl-1,2,3,6-tetrahydro-3-methyl-4-pyrolidino-pyridine (14 g) and propargyl bromide (6 g) in dry benzene (50 ml) was stirred at room temperature under nitrogen for 40 hours. The mixture was then heated on a steam bath for one-half hour with water (200 ml). The organic layer was collected, dried over magnesium sulphate and evaporated, leaving 11.6 g of the crude title compound (about 50% by g.l.c.) as a red oil.

Workup

  1. customThe organic layer was collected
  2. dry with materialdried over magnesium sulphate
  3. customevaporated

Sources & evidence

ORD record
ord-1d6c65e65a0c449ab87d2219c3506234
Source dataset
uspto-grants-1976_11
Patent number
US03992544

Reaction notes

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