3-Chlorobenzaldehyde → HCID 54255275, compound

HRID 1730519Notes

Reaction equation

HRID 1730519 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH2:10]([O:12][C:13](=[O:20])[CH:14]=[C:15]([NH2:19])[O:16][CH2:17][CH3:18])[CH3:11]>C(O)(C)C>[CH2:10]([O:12][C:13]([C:14]1[CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[C:2]([Cl:1])[CH:3]=2)[CH:14]([C:13]([O:12][CH2:10][CH3:11])=[O:20])[C:15]([O:16][CH2:17][CH3:18])=[N:19][C:15]=1[NH2:19])=[O:20])[CH3:11]

Participants

4

Reactant 2

HCID 114773-ChlorobenzaldehydeHCID 278451beta-Aminobeta-ethoxyacrylic acid ethyl ester

Product 1

HCID 54255275HCID 54255275, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Upon boiling a solution of 7.1 g of 3-chlorobenzaldehyde and 15.9 g of 3-amino-3-ethoxyacrylic acid ethyl ester in 40 ml of isopropanol for 8 hours, 2-amino-4-(3-chlorophenyl)-6-ethoxy-4,5-dihydropyridine-3,5-dicarboxylic acid diethyl ester of melting point 121° C is obtained.

Workup

  1. customfor 8 hours

Sources & evidence

ORD record
ord-49e87cf16e3c4db9a09ec1a400f0cb17
Source dataset
uspto-grants-1976_11
Patent number
US03992545

Reaction notes

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