Hydrochloric Acid → HCID 21497124, compound

Participants

Reaction Steps

1-[p-[(7-chloro-4-quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide (Example 1, supra.) and a mixture of hydrochloric acid in ethanol are admixed together, in proportions such that the molar proportion of acid istwice the molar proportion of the oxide reactant. The reaction mixture is evaporated to dryness under reduced atmospheric pressure and the residue recrystallized from ethanol to give 1-[p-[(7-chloro-4-quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide dihydrochloride.

Provenance & Evidence