Hydrochloric Acid → HCID 21497124, compound

HRID 1730526Notes

Reaction equation

HRID 1730526 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:28]=[CH:27][C:16]([C:17]([N:19]4[CH2:24][CH2:23][N+:22]([O-:26])([CH3:25])[CH2:21][CH2:20]4)=[O:18])=[CH:15][CH:14]=3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[ClH:29]>C(O)C>[ClH:1].[ClH:29].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:28]=[CH:27][C:16]([C:17]([N:19]4[CH2:20][CH2:21][N+:22]([O-:26])([CH3:25])[CH2:23][CH2:24]4)=[O:18])=[CH:15][CH:14]=3)=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21399757HCID 21399757, compound

Product 1

HCID 21497124HCID 21497124, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-[p-[(7-chloro-4-quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide (Example 1, supra.) and a mixture of hydrochloric acid in ethanol are admixed together, in proportions such that the molar proportion of acid istwice the molar proportion of the oxide reactant. The reaction mixture is evaporated to dryness under reduced atmospheric pressure and the residue recrystallized from ethanol to give 1-[p-[(7-chloro-4-quinolyl)amino]benzoyl]-4-methylpiperazine-4-oxide dihydrochloride.

Workup

  1. customThe reaction mixture is evaporated to dryness under reduced atmospheric pressure
  2. customthe residue recrystallized from ethanol

Sources & evidence

ORD record
ord-eb67b9c6d170464087504bf3a00e38e6
Source dataset
uspto-grants-1976_11
Patent number
US03992382

Reaction notes

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