4-Fluoroaniline → HCID 54695922, compound

HRID 1730537Notes

Reaction equation

HRID 1730537 reaction equation
CO[C:3]([C:5]1[N:6]([CH3:22])[S:7](=[O:21])(=[O:20])[C:8]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=[CH:12][C:9]=2[C:10]=1[OH:11])=[O:4].[F:23][C:24]1[CH:30]=[CH:29][C:27]([NH2:28])=[CH:26][CH:25]=1>C1(C)C(C)=CC=CC=1>[F:23][C:24]1[CH:30]=[CH:29][C:27]([NH:28][C:3]([C:5]2[N:6]([CH3:22])[S:7](=[O:21])(=[O:20])[C:8]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]=[CH:12][C:9]=3[C:10]=2[OH:11])=[O:4])=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 97314-FluoroanilineHCID 546906514-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide

Product 1

HCID 54695922HCID 54695922, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

N-(4-Fluorophenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide was prepared analogous to Example 1 from 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide and 4-fluoroaniline. Yield: 89% of theory; m.p. 284°-285° C (decomp.; from xylene).

Sources & evidence

ORD record
ord-dae80c3767ec40189b5c43521d25b1f4
Source dataset
uspto-grants-1976_11
Patent number
US03992535

Reaction notes

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