反应详情

A mixture consisting of 9.53 gm (0.03 mol) of 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide, 3.8 gm (0.04 mol) of 2-aminopyridine and 250 ml of anhydrous xylene was refluxed for 14 hours in a Soxhlet apparatus equippedwith a 4-A-molecular sieve. After cooling and standing overnight, the crystals which had formed were suction-filtered off and recrystallized from ethylene chloride, yielding 5.4 gm (42% of theory) of the crystallinecompound of the formula ##SPC14##

1. temperaturewas refluxed for 14 hours in a Soxhlet apparatus equippedwith a 4-A-molecular sieve
2. temperatureAfter cooling
3. customthe crystals which had formed
4. filtrationwere suction-filtered off
5. customrecrystallized from ethylene chloride
6. customyielding 5.4 gm (42% of theory) of the crystallinecompound of the formula