4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide → HCID 68140774, compound

HRID 1730554Notes

Reaction equation

HRID 1730554 reaction equation
C[O:2][C:3]([C:5]1[N:6]([CH3:22])[S:7](=[O:21])(=[O:20])[C:8]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]=[CH:12][C:9]=2[C:10]=1[OH:11])=O.[NH2:23][CH:24]1[N:28]=[C:27]2[CH2:29][CH2:30][S:31][CH:32]=[C:26]2[S:25]1>C1(C)C(C)=CC=CC=1>[N:28]1[CH:24]([NH:23][C:3]([C:5]2[N:6]([CH3:22])[S:7](=[O:20])(=[O:21])[C:8]3[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[CH:13]=[CH:12][C:9]=3[C:10]=2[OH:11])=[O:2])[S:25][C:26]2[C:27]=1[CH2:29][CH2:30][S:31][CH:32]=2

Participants

4

Reactant 2

HCID 546906514-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxideHCID 68143541HCID 68143541, compound

Product 1

HCID 68140774HCID 68140774, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

N-(5,6-Dihydro-7H-thiopyrano[4,3-d]thiazol-2-yl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide was prepared analogous toExample 22 from 4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acid methylester-1,1-dioxide and 2-amino-5,6-dihydro-7H-thiopyrano[4,3-d]thiazole. yield: 67% of theory: m.p. 255° C (decomp.; from xylene).

Sources & evidence

ORD record
ord-09c24a3e1f8e478f988666e58f5388c9
Source dataset
uspto-grants-1976_11
Patent number
US03992535

Reaction notes

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