HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → N-Cyclohexylacetoacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Diketene | HCID 12661 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | N-Cyclohexylacetoacetamide | HCID 70805 | — |
Reaction Steps
A solution of diketene (42 g.) in benzene (74 ml.) is added dropwise with vigorous stirring to a solution of cyclohexylamine (49.6 g.) in benzene (125 ml.). The rate of addition is adjusted so that a gentle reflux is maintained. The benzene is removed under vacuum and the yellow oil crystallizes upon trituation with hexane. A yield of 88.7 g. of product melting at 66°-69° C. is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03993637 |
| Source dataset | uspto-grants-1976_11 |
| ORD ID | ord-f41e8808f013472d95e642b7057a0f3c |
| Source note | uspto-grants-1976_11 |