4-Chlorobenzaldehyde → HCID 21496062, compound

HRID 1730633Notes

Reaction equation

HRID 1730633 reaction equation
[C:1]([C:4]1[C:5]([NH2:17])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])[NH:7][C:8]=1[CH3:9])(=[O:3])[CH3:2].[Cl:18][C:19]1[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=1>>[C:1]([C:4]1[C:5]([NH:17][CH2:23][C:22]2[CH:25]=[CH:26][C:19]([Cl:18])=[CH:20][CH:21]=2)=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])[NH:7][C:8]=1[CH3:9])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 77264-ChlorobenzaldehydeHCID 41888Ethanone, 1-(4-amino-2-methyl-5-(2-methylphenyl)-1H-pyrrol-3-yl)-

Product 1

HCID 21496062HCID 21496062, compound

Procedure

The title compound (M.p. 167°-70° C) is prepared from 4-acetyl-3-amino-5-methyl-2-(o-tolyl)-pyrrole (m.p. 258° C), obtained substantially in the same way as compound A), by transforming into the corresponding p-chlorobenzylidene derivative (m.p. 215° C) by reaction with p-chlorobenzaldehyde and subsequent catalytic hydrogenation.

Workup

  1. customobtained substantially in the same way as compound A),

Sources & evidence

ORD record
ord-c57b60805db44a8b93edaa7e005a407c
Source dataset
uspto-grants-1976_11
Patent number
US03993650

Reaction notes

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